Cough and reflux esophagitis in children: their co-existence and airway cellularity.

摘要: There are no prospective studies that have examined for chronic cough in children without lung disease but with gastroesophageal reflux (GER). In otherwise healthy undergoing flexible upper gastrointestinal endoscopy (esophago-gastroscopy), the aims of study were to (1) define frequency relation symptoms GER, (2) examine if and esophagitis (RE) different airway cellularity microbiology bronchoalveolar lavage (BAL) when compared those without. Data specific (>4-weeks), GER severity collected. Children aged <16-years (n = 150) defined as 'coughers' (C+) a history association their was elicited before BAL obtained during elective esophago-gastroscopy. Presence on esophageal biopsies considered positive (E+). C+ 69) just likely C- 81) esophagitis, odds ratio 0.87 (95%CI 0.46, 1.7). Median neutrophil percentage significantly between groups; highest C+E- (7, IQR 28) lowest C-E+ (5, 6). bacterial culture occurred 20.7% more present current coughers (OR 3.37, 95%CI 1.39, 8.08). Airway neutrophilia (median 20%, 34) higher cultures than (5%, 4; p 0.0001). disease, common co-existence is independent occurrence esophagitis. these be related infection not