Inclusion complexes of nitroxides of pyrrolidine and imidazoline series with cucurbit[7]uril.
作者： I. Kirilyuk , D. Polovyanenko , S. Semenov , I. Grigor’ev , O. Gerasko
DOI: 10.1021/JP9103678
关键词: Nitroxide mediated radical polymerization 、 Stereochemistry 、 Polymer chemistry 、 Alkali metal 、 Ascorbic acid 、 Electron paramagnetic resonance 、 Chemistry 、 Hyperfine structure 、 Pyrrolidine 、 Rotational correlation time 、 Imidazoline receptor
摘要: Inclusion of nitroxides into the cavity molecular nanocontainers may prevent or significantly retard nitroxide reactions with cellular reductans and increase lifetime. This paper is aimed at studying possible applications cucurbit[7]uril (CB7) as a nanocontainer for pH-sensitive probes. complexes CB7 different nitroxides--3-aminomethyl-proxyl (AMP), 3-hydroxymethyl-proxyl (HMP), 4-amino-2,2,5,5-tetramethyl-2,5-dihydroimidazole-1-oxyl (ATI), 2,2,4,5,5-pentamethyl-2,5-dihydroimidazole-1-oxyl (MTI)--were studied. It was found that reversible formation inclusion AMP@CB7, AMPH(+)@CB7, HMP@CB7, ATIH(+)@CB7, MTIH(+)@CB7 accompanied by decrease hyperfine interaction (HFI) constant on nitrogen group 5-7-fold rotational correlation time monitored electron paramagnetic resonance (EPR). The binding constants nitroxide@CB7 were determined, influence alkali metal ions pH equilibrium between free encapsulated EPR spectra mixtures protonable to be more sensitive changes than pure nitroxides, apparent pK these concentration. showed higher resistance chemical reduction ascorbic acid compared nitroxides. Thus, can used improvement functional properties
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