Prospective, observational practice survey of applied skin care and management of cetuximab-related skin reactions: PROSKIN study.

摘要: The study aimed to investigate strategies prevent and treat cetuximab-induced skin reactions their perceived effectiveness in patients with metastatic colorectal cancer (mCRC) recurrent/metastatic squamous cell of the head neck (SCCHN). This open-label, prospective observational was conducted Switzerland. A total 125 were included (n = 91 mCRC, n = 34 SCCHN; mean age 63.3 years; 73.6% males). frequency acneiform rash grade ≥ 2 increased from 12.6% at week 2 21.7% 16. proportion who reported no reaction decreased 75.6% 43.3% most frequently used products any time observation moisturizing (77.6%), lipid-regenerating (56.8%) or urea-containing (52%), systemic antibiotics (49.6%), vitamin K1 cream (43.2%). There clear pattern for all product classes: given patients, either showed effect a moderate/strong effect, consistently over time. great variety low-cost general care commonly used. According physician’s preference, are an appropriate approach cetuximab-related toxicity.