A review of acrylamide neurotoxicity. Part I. Properties, uses and human exposure.

摘要: Two factors have stimulated the present intense investigation of acrylamide neurotoxicity. These are health hazard accompanying vast and increasing industrial production acrylamide, promise illuminating mechanism dying-back disease in human nervous system by employing as an experimental tool. The paper discusses uses its regulation, prevention, detection clinico-pathologic features intoxication. Bearing on cumulative nature neurotoxicity, separate sections review chemistry, biochemistry, toxicology metabolic fate acrylamide. Clinical, electrophysiological morphologic data acute chronic intoxication animals, possible etiologies damage, considered detail a companion (P. S. Spencer H. Schaumburg, Canadian Journal Neurological Sciences, 1:151, 1974).