Plasma ouabain-like factor during acute and chronic changes in sodium balance in essential hypertension.

摘要: An ouabain-like factor has been implicated repeatedly in salt-sensitive hypertension as a natriuretic agent. However, the response of plasma to acute and chronic variation body sodium is unclear. We studied 138 patients with essential who underwent an volume expansion/contraction maneuver (2 days) 20 entered blind randomized crossover design involving chronically controlled intake depletion (170 70 mmol/d; 2 weeks each period). In both studies, levels were higher during (acute: 338.8+/-17.4 402.7+/-22.8 pmol/L for baseline low sodium, respectively, P<0.01; chronic: 320.4+/-32.0 versus 481.0+/-48.1 pmol/L, P=0.01). No significant change was observed after 2-hour saline infusion (333.4+/-23.9 pmol/L) or (402.1+/-34.9 pmol/L). When divided into salt-resistant groups, no differences groups at protocols: salt resistant (n=69, 340.1+/-25.9 sensitive 337.4+/-23.6 (n=11, 336.0+/-53.2) (n=9, 301.1+/-331.4 circulating increased by groups. These results demonstrate that raised specifically maneuvers promote loss sodium. Acute expansion fluids isotonic not stimulus factor. Moreover, basal do differ among hypertension. Taken together, these new suggest involved adaptation humans argue against hypothesis hormone.