Dissemination of the mcr-1 colistin resistance gene
作者： Chanping Zhi , Luchao Lv , Lin-Feng Yu , Yohei Doi , Jian-Hua Liu
DOI: 10.1016/S1473-3099(16)00063-3
关键词: Biology 、 Gene 、 MCR-1 、 Antibiotics 、 Plasmid 、 Colistin 、 Virology 、 Colistin resistance 、 Klebsiella pneumoniae 、 Escherichia coli
摘要: www.thelancet.com/infection Vol 16 March 2016 289 1 Liu Y-Y, Wang Y, Walsh TR, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings China: a microbiological molecular biological study. Lancet Infect Dis 2016; 16: 161–68. 2 Paterson DL, Harris PN. Colistin resistance: major breach our last line defence. 132–33. 3 Li J, Nation RL, Turnidge JD, Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections. 2006; 6: 589–601. 4 X, H, Zhao C, Novel NDM-9 metallo-β-lactamase identifi ed from ST107 Klebsiella pneumoniae strain isolated China. Int J Antimicrob Agents 2014; 44: 90–91. 5 Yang W, F33: A-: B-, IncHI2/ST3, IncI1/ST71 plasmids drive dissemination fosA3 blaCTX-M-55/-14/-65 Escherichia coli chickens Front Microbiol 5: 688. 6 He L, Partridge SR, Complete nucleotide sequence pHN7A8, an F33:A-:Btype epidemic plasmid carrying blaCTX-M-65, rmtB Chemother 2013; 68: 46–50. to other pathogens, which might result untreatable Thus, spread mcr-1, especially into strains that are already resistant carbapenems, must be stopped.
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