Superficial cervicovaginal myofibroblastoma: Fourteen cases of a distinctive mesenchymal tumor arising from the specialized subepithelial stroma of the lower female genital tract

摘要: The clinicopathologic features and immunohistochemical profiles of 14 cases a distinctive mesenchymal tumor that arises in the superficial lamina propria cervix vagina is histologically distinguishable from mesodermal (fibroepithelial) stromal polyp, including cellular (pseudosarcomatous) variant, angiomyofibroblastoma, aggressive angiomyxoma, other well-recognized lesions occur this location, are described. presented as polypoid (n = 10) or nodular 4) mass 12) 2) women ranging age 40 to 74 years (median, 58 years). tumors were subepithelial well circumscribed, ranged size 1 6.5 cm. (mean, 2.7 cm). Microscopically, process was moderately highly composed relatively bland spindled stellate-shaped cells embedded finely collagenous stroma punctuated by myxoid edematous foci 9 cases. characteristically had multipatterned architecture with focally assuming lacelike/sievelike growth pattern more stroma-rich areas vague fascicular foci. Mitotic activity minimal, no atypical mitotic figures identified. immunoreactive (in decreasing order relative strength) for vimentin (5 5 cases), estrogen (10 10 progesterone cases) receptors, desmin (13 13 CD34 (11 alpha-smooth muscle actin 11 muscle-specific (2 8 cases). antibodies highlighted interconnecting, dendritic processes associated many cells. No immunoreactivity detected S100 protein, epithelial membrane antigen, keratins. Follow-up data patients (range, 20 years; median, 4 years) showed recurrence metastasis after local excision. term "superficial cervicovaginal myofibroblastoma" proposed because it reflects distinguishing benign, site-specific tumor. probably neoplastic proliferation hormonally responsive native unique layer normally found through endocervix vulva adult women.