作者: Alison H. Trainer
DOI: 10.1007/978-1-4419-1145-2_10
关键词: Signs and symptoms 、 Colorectal cancer 、 Internal medicine 、 Clinical manifestation 、 Colorectal surgery 、 Familial adenomatous polyposis 、 Gastroenterology 、 Familial Adenomatous Polyposis Coli 、 Adenomatous polyposis coli 、 Penetrant (biochemical) 、 Medicine
摘要: The most important clinical manifestation of Familial Adenomatous Polyposis (FAP) is a profuse polyposis predisposing to colorectal cancer. This picture emphasises the fundamental cellular role APC in tumorigenesis. As prophylactic surgery has significantly reduced mortality associated with this disorder, other less penetrant signs and symptoms condition are becoming more clinically relevant. Highlighting these problems will help improve quality life for patients FAP may have additional benefit shedding new light on possible functions protein.