Modulation of actin dynamics by Rac1 to target cognitive function.

摘要: The small GTPase Rac1 is well known for regulating actin cytoskeleton reorganization in cells. Formation of extensions at the surface cell required migration and even invasion metastases. Because an elevated level hyperactivation this protein has been associated with metastasis cancer, direct regulators are currently envisioned as a potential strategy to treat certain cancers. Less research, however, done regarding role GTP-binding brain development, where it important dendritic spine morphogenesis through regulation actin. Alteration development spinogenesis often mental disorders. learning formation memories brain. appears be dysregulated neurodevelopmental disorders that present all these three alterations: retardation, atypical synaptic plasticity aberrant morphology. Thus, develop novel therapies rescuing cognitive impairment, reasonable approach might target protein, Rac1, which plays pivotal directing signals regulate dynamics, turn have effect cytoarchitecture function. It possible drugs activation function could modulate representing candidates repair intellectual disability abnormalities. Herein, we list current inhibitors fulfill together summary latest findings concerning their they relate neuronal studies. While different type cells, also Abnormal disabilities, abnormal morphology spines modulation activity using reestablish