Results of salvage abdominoperineal resection for anal cancer after radiotherapy

摘要: PURPOSE: Nonsurgical treatment of anal cancer by radiotherapy alone or combined with chemotherapy is the standard therapy for epidermoid carcinoma canal. Surgery only recommended failures. Very few studies have been devoted to outcome this salvage surgery. The aim study evaluate these results. METHODS: A retrospective review from 1986 1995 revealed 21 patients residual recurrent canal after initial radiotherapy, operated on abdominoperineal resection. Patients were reviewed as age, gender, treatment, any symptoms recurrence, duration until diagnosis imaging, and outcome. RESULTS: None had known lymph node involvement metastases at Eleven disease (positive biopsy less than 6 months end radiotherapy) 10 tumor recurrence (more cessation treatment). Recurrence occurred a mean 15 (range, 9–41) radiotherapy. All underwent an Pathologic examination specimens showed complete excision in all cases except one two cases. There was no perioperative mortality. follow-up surgery 40 months; lost follow-up. Of patients, died 11 lived, whom 9 are free. overall survival rate three years resection 58 percent. (vs. recurrence) 72 percent 29 percent) five 60 0 percent;P=0.06). CONCLUSIONS: Salvage can be expected yield number survivors disease, but low suggests need additional postoperative if performed.