Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast
作者： Daniel J. Lew , Vjekoslav Dulić , Steven I. Reed
DOI: 10.1016/0092-8674(91)90042-W
关键词: Cyclin D 、 Cell cycle 、 Cyclin A2 、 Cyclin Gene 、 Low Molecular Weight Cyclin E 、 Cyclin 、 Genetics 、 Biology 、 Gene 、 Cyclin A
摘要: We have isolated a number of cDNAs derived from human mRNAs that are able to substitute for G1 cyclin genes in S. cerevisiae. Several these encode cyclins A, B1, and B2. Three novel been identified, which we call C, D, E. The proteins sufficiently distantly related the other members family each as constitute three new classes cyclins. Cyclin C E accumulate periodically through cell cycle, peaking at different times G1.
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