Evaluation of dysprosia aerogels as drug delivery systems: a comparative study with random and ordered mesoporous silicas.
作者： Abhishek Bang , Anand G. Sadekar , Clayton Buback , Brice Curtin , Selin Acar
DOI: 10.1021/AM4059217
关键词: Materials science 、 Nanostructure 、 Chemical engineering 、 Mesoporous silica 、 Aqueous solution 、 Nanotechnology 、 Drug release rate 、 Coating 、 Biocompatibility 、 Drug delivery 、 Mesoporous material
摘要: Biocompatible dysprosia aerogels were synthesized from DyCl3·6H2O and reinforced mechanically with a conformal nano-thin-polyurea coating applied over their skeletal framework. The random mesoporous space of was filled up to about 30% v/v paracetamol, indomethacin, or insulin, the drug release rate monitored spectrophotometrically in phosphate buffer (pH = 7.4) 0.1 M aqueous HCl. uptake study conducted comparatively polyurea-crosslinked silica aerogels, as well as-prepared (native) perforated ordered 7 nm tubes hexagonal packing. Drug nanostructures (silica dysprosia) higher (30–35% w/w) slower (typically >20 h) relative (19–21% w/w, <1.5 h, respectively). data fitted flux equation consisting three additive terms that correspond stored successiv...
acs.org
mst.edu
sci-hub.se 参考文章(72)
Andrew Z Wang, Vaishali Bagalkot, Christophoros C Vasilliou, Frank Gu, Frank Alexis, Liangfang Zhang, Mariam Shaikh, Kai Yuet, Michael J Cima, Robert Langer, Philip W Kantoff, Neil H Bander, Sangyong Jon, Omid C Farokhzad, None, Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy ChemMedChem. ,vol. 3, pp. 1311- 1315 ,(2008) , 10.1002/CMDC.200800091
Atul Katti, Nilesh Shimpi, Samit Roy, Hongbing Lu, Eve F. Fabrizio, Amala Dass, Lynn A. Capadona, Nicholas Leventis, Chemical, Physical, and Mechanical Characterization of Isocyanate Cross-linked Amine-Modified Silica Aerogels Chemistry of Materials. ,vol. 18, pp. 285- 296 ,(2006) , 10.1021/CM0513841
Di Zhao, Jing Yu, Wenhai Huang, Nai Zhou, Deping Wang, Wei Yin, Yaqing Chen, Dysprosium lithium borate glass mircrospheres for radiation synovectomy: The in vitro and in vivo performance evaluation Materials Science and Engineering: C. ,vol. 30, pp. 970- 974 ,(2010) , 10.1016/J.MSEC.2010.04.011
Nicholas Leventis, Three Dimensional Core-shell Superstructures: Mechanically Strong Aerogels Accounts of Chemical Research. ,vol. 40, pp. 874- 884 ,(2007) , 10.1021/AR600033S
PAWEŁ SZYMAŃSKI, MAGDALENA MARKOWICZ, ELŻBIETA MIKICIUK-OLASIK, NANOTECHNOLOGY IN PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS: DENDRIMERS NANO. ,vol. 06, pp. 509- 539 ,(2011) , 10.1142/S1793292011002871
María Vallet-Regí, Ordered Mesoporous Materials in the Context of Drug Delivery Systems and Bone Tissue Engineering Chemistry: A European Journal. ,vol. 12, pp. 5934- 5943 ,(2006) , 10.1002/CHEM.200600226
Michael L. Quillin, Brian W. Matthews, Accurate calculation of the density of proteins. Acta Crystallographica Section D-biological Crystallography. ,vol. 56, pp. 791- 794 ,(2000) , 10.1107/S090744490000679X
C Medina, M J Santos-Martinez, A Radomski, O I Corrigan, M W Radomski, Nanoparticles: pharmacological and toxicological significance. British Journal of Pharmacology. ,vol. 150, pp. 552- 558 ,(2007) , 10.1038/SJ.BJP.0707130
Nicholas Leventis, Chariklia Sotiriou-Leventis, Guohui Zhang, Abdel-Monem M. Rawashdeh, Nanoengineering Strong Silica Aerogels Nano Letters. ,vol. 2, pp. 957- 960 ,(2002) , 10.1021/NL025690E
Axel Schlossbauer, Simon Warncke, Philipp M. E. Gramlich, Johann Kecht, Antonio Manetto, Thomas Carell, Thomas Bein, A programmable DNA-based molecular valve for colloidal mesoporous silica. Angewandte Chemie. ,vol. 49, pp. 4734- 4737 ,(2010) , 10.1002/ANIE.201000827