Juvenile megaesophagus in PKCα-deficient mice is associated with an increase in the segment of the distal esophagus lined by smooth muscle cells.
作者： Elena Noe , Christoph Tabeling , Jan-Moritz Doehn , Jan Naujoks , Bastian Opitz
DOI: 10.1016/J.AANAT.2014.04.001
关键词: Skeletal muscle 、 Embryonic stem cell 、 Anatomy 、 Protein kinase C 、 Inflammation 、 Fibrosis 、 Biology 、 Alpha (ethology) 、 Achalasia 、 Megaesophagus 、 Pathology
摘要: Abstract Megaesophagus in mice has been associated with several genetic defects. In the present study we expand range of genes esophageal function and morphology by protein kinase C alpha (PKCα). PKCα-deficient showed a six times increased prevalence megaesophagus at age 9–10 weeks compared to wild-type animals. contrast, restricted number 14-month-old animals both genotypes similar was found. an portion distal esophagus lined smooth muscle cells. Achalasia-like degeneration or loss neuronal cells, inflammation fibrosis not any The results therefore suggest that PKCα expression is delayed replacement embryonic skeletal consecutive young mice, which, however, same advanced age.
sci-hub.se 参考文章(28)
G. Gordillo-González, Y. P. Guatibonza, I. Zarante, P. Roa, L. A. Jacome, A. Hani, Achalasia familiar : report of a family with an autosomal dominant pattern of inherence Diseases of The Esophagus. ,vol. 24, ,(2011) , 10.1111/J.1442-2050.2010.01124.X
K. S. Murthy, J. R. Grider, J. F. Kuemmerle, G. M. Makhlouf, Sustained muscle contraction induced by agonists, growth factors, and Ca2+ mediated by distinct PKC isozymes American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 279, ,(2000) , 10.1152/AJPGI.2000.279.1.G201
E. Bruder, A.-L. Rougemont, R.I. Furlano, J.F. Schneider, J. Mayr, F.-M. Haecker, K. Beier, J. Schneider, P. Weber, T. Berberich, G. Cathomas, W.A. Meier-Ruge, Motilitätsstörungen des Ösophagus Pathologe. ,vol. 34, pp. 118- 132 ,(2013) , 10.1007/S00292-012-1727-0
Fawaz Chikh Torab, Moustafa Hamchou, Gabriel Ionescu, Ahmed H Al-Salem, None, Familial achalasia in children. Pediatric Surgery International. ,vol. 28, pp. 1229- 1233 ,(2012) , 10.1007/S00383-012-3186-3
Raj K. Goyal, Arun Chaudhury, Pathogenesis of Achalasia: Lessons From Mutant Mice Gastroenterology. ,vol. 139, pp. 1086- 1090 ,(2010) , 10.1053/J.GASTRO.2010.08.013
Cristian Vailati, Giorgia Mazzoleni, Pier Alberto Testoni, Sandro Passaretti, An Italian family with inherited achalasia. Digestive and Liver Disease. ,vol. 45, pp. 524- 525 ,(2013) , 10.1016/J.DLD.2013.01.009
Nayoung Kim, Weibiao Cao, In Sung Song, Chung Yong Kim, Karen M. Harnett, Ling Cheng, Michael P. Walsh, Piero Biancani, Distinct kinases are involved in contraction of cat esophageal and lower esophageal sphincter smooth muscles. American Journal of Physiology-cell Physiology. ,vol. 287, ,(2004) , 10.1152/AJPCELL.00390.2003
Cristiane Hallal, Carlos O. Kieling, Daltro L. Nunes, Cristina T. Ferreira, Guilherme Peterson, Sérgio G. S. Barros, Cristina A. Arruda, José C. Fraga, Helena A. S. Goldani, Diagnosis, misdiagnosis, and associated diseases of achalasia in children and adolescents: a twelve-year single center experience. Pediatric Surgery International. ,vol. 28, pp. 1211- 1217 ,(2012) , 10.1007/S00383-012-3214-3
Farnoosh Farrokhi, Michael F Vaezi, Idiopathic (primary) achalasia Orphanet Journal of Rare Diseases. ,vol. 2, pp. 38- 38 ,(2007) , 10.1186/1750-1172-2-38
Jürgen Wörl, Winfried L. Neuhuber, Ultrastructural analysis of the smooth‐to‐striated transition zone in the developing mouse esophagus: Emphasis on apoptosis of smooth and origin and differentiation of striated muscle cells Developmental Dynamics. ,vol. 233, pp. 964- 982 ,(2005) , 10.1002/DVDY.20436