Modified peptidoglycan precursors produced by glycopeptide-resistant enterococci
作者： Janet Messer , Peter E. Reynolds
DOI: 10.1111/J.1574-6968.1992.TB05314.X
关键词: Biosynthesis 、 Glycopeptide 、 Peptidoglycan 、 Enterococcus faecium 、 Lysine 、 Biochemistry 、 Dehydrogenase 、 Biology 、 Residue (chemistry) 、 Oxidoreductase
摘要: Cytoplasmic precursors of the peptidoglycan biosynthetic pathway were purified from vancomycin-treated, glycopeptide-sensitive and -resistant strains Enterococcus faecium. Resistance was due to production a modified precursor, UDP-MurNAc-l-Ala-d-Glu-l-Lys-d-Ala-d-lactate, where lactate identified on basis mass precursor its ability act as substrate for d-lactate dehydrogenase after release precursor. The presence residue instead d-alanine in terminal position would hinder formation vancomycin-precursor complex, without preventing incorporation into mature peptidoglycan.
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