Alcohol metabolism and cancer risk.
作者： Helmut K Seitz , Peter Becker
DOI:
关键词: Biology 、 Alcohol 、 Cancer research 、 Metabolite 、 Biochemistry 、 Enzyme 、 Ethanol 、 Acetaldehyde 、 Aldehyde dehydrogenase 、 Ethanol metabolism 、 Alcohol dehydrogenase
摘要: Chronic alcohol consumption increases the risk for cancer of organs and tissues respiratory tract upper digestive (i.e., aerodigestive tract), liver, colon, rectum, breast. Various factors may contribute to development pathogenesis) alcohol-associated cancer, including actions acetaldehyde, first most toxic metabolite metabolism. The main enzymes involved in acetaldehyde metabolism are dehydrogenase (ADH) aldehyde (ALDH), which encoded by multiple genes. Because some these genes exist several variants polymorphic), certain result elevated levels, presence predispose cancers. Several mechanisms alcohol-related development. Acetaldehyde itself is a cancer-causing substance experimental animals reacts with DNA form cancer-promoting compounds. In addition, highly reactive, oxygen-containing molecules that generated during pathways can damage DNA, thus also inducing tumor Together other related chronic consumption, metabolism-related increase heavy drinkers.
questia.com参考文章(37)
Jo L. Freudenheim, Christine B. Ambrosone, Kirsten B. Moysich, John E. Vena, Saxon Graham, James R. Marshall, Paola Muti, Rosemary Laughlin, Takuma Nemoto, Lea C. Harty, G. Adam Crits, Arthur W.K. Chan, Peter G. Shields, Alcohol dehydrogenase 3 genotype modification of the association of alcohol consumption with breast cancer risk. Cancer Causes & Control. ,vol. 10, pp. 369- 377 ,(1999) , 10.1023/A:1008950717205
Alcohol, tobacco and cancer Alcohol, tobacco and cancer.. ,(2006) , 10.1159/ISBN.978-3-318-01338-2
Mikko Salaspuro, Ville Salaspuro, Helmut K. Seitz, Interaction of Alcohol and Tobacco in Upper Aerodigestive Tract and Stomach Cancer Karger Publishers. pp. 48- 62 ,(2006) , 10.1159/000095014
Marta Blangiardo, Vincenzo Bagnardi, Giovanni Corrao, Carlo La Vecchia, Alcohol Consumption and the Risk of Cancer: A Meta-Analysis Alcohol Research & Health. ,vol. 25, pp. 263- 270 ,(2001)
Qinghui Meng, Michael Yadegari, Bin Gao, Jason Grossman, Itzhak D. Goldberg, Saijun Fan, Eliot M. Rosen, Alcohol stimulates estrogen receptor signaling in human breast cancer cell lines. Cancer Research. ,vol. 60, pp. 5635- 5639 ,(2000)
Seitz Hk, Coutelle C, Quattrochi P, Roth Hj, Schneeweiss A, Höhn B, Bastert G, Benesova M, Schmidt-Gayk H, Oneta Cm, Risk factors in alcohol associated breast cancer: alcohol dehydrogenase polymorphism and estrogens. International Journal of Oncology. ,vol. 25, pp. 1127- 1159 ,(2004) , 10.3892/IJO.25.4.1127
Helmut K. Seitz, Ulrich A. Simanowski, Felix T. Garzon, James M. Rideout, Timothy J. Peters, Armin Koch, Martin R. Berger, Henner Einecke, Matthias Maiwald, Possible role of acetaldehyde in ethanol-related rectal cocarcinogenesis in the rat. Gastroenterology. ,vol. 98, pp. 406- 413 ,(1990) , 10.1016/0016-5085(90)90832-L
Helmut K. Seitz, Felix Stickel, Nils Homann, Pathogenetic mechanisms of upper aerodigestive tract cancer in alcoholics. International Journal of Cancer. ,vol. 108, pp. 483- 487 ,(2004) , 10.1002/IJC.11600
W. Bosron, T. Ehrig, T.-K. Li, Genetic factors in alcohol metabolism and alcoholism. Seminars in Liver Disease. ,vol. 13, pp. 126- 135 ,(1993) , 10.1055/S-2007-1007344
G. Obe, R. Jonas, S. Schmidt, Metabolism of ethanol in vitro produces a compound which induces sister-chromatid exchanges in human peripheral lymphocytes in vitro: Acetaldehyde not ethanol is mutagenic Mutation Research Letters. ,vol. 174, pp. 47- 51 ,(1986) , 10.1016/0165-7992(86)90075-8