The ketogenic diet: 1997.

摘要: There has been a dramatic resurgence of interest in the ketogenic diet during past several years. For many children with difficult-to-control epilepsy, presents an alternative approach to trying multiple medications. The diet's current success rate, when properly executed, greatly exceeds that medications which have recently become available. Its side effects, both cognitive and allergic, appear fewer than most available is also cheaper new anticonvulsants. Even though we now know works, still do not how it works. Nor anticonvulsants work. mechanism action appears rely on fundamental change brain's metabolism from glucose-based energy substrate ketone-based substrate. This is, some fashion, critical maintenance seizure threshold. Why should source make difference threshold? threshold occur without affecting ability carry out its normal complex functions. Could utilization for control be different brain function? If so possible study metabolic differences between two develop biochemistry differentiated cognition function. successful controlling or ameliorating broad spectrum types etiologies. Perhaps then, common pathways, independent type, are used initiation spread electrical seizures. Based clinical experience limited research data, would seizures epilepsies must pathways them susceptible treatment therapy. could understand "works," changing glucose substrate' ketone body anticonvulsant, then perhaps medication developed simulate biochemical effects diet. Such major departure neuroscience epilepsy. offers paradigm think about epilepsy treatment, will stimulate approaches this often devastating condition.