Diffuse malignant mesothelioma: a review.

摘要: Diffuse malignant mesothelioma is a signal tumor of asbestos exposure. Mesothelioma incidence has been steadily rising during the past two decades, reflecting increases in use and following World War II. The onset disease follows exposure by 25 to 40 years. dose-response relationship appears be much lower than that for asbestosis or lung cancer-it not known whether current levels will entail risk 30 years hence. There no synergistic additive interaction with smoking this tumor. Current knowledge indicates pleural plaques, per se, do increase beyond previous alone. Durable fibers high aspect ratios, especially amphiboles, are associated experimental induction. Treatment modalities including surgical procedures chemotherapy doxorubicin 5-azacytidine offer prospects palliation.