Rethinking the Local Therapy of Breast Cancer: Integration of Biology and Anatomy

摘要: Local control has traditionally been considered a function of disease burden. is now known to differ among biologic subtypes breast cancer and greatly improved with the use systemic therapy. This offers opportunities for decreasing morbidity treatment individualizing local The smaller margins in breast-conserving surgery elimination axillary dissection some node-positive patients are current examples leveraging benefits therapy reduce surgery. Emerging evidence indicates that molecular profiling can identify at high low risk locoregional recurrence after more accurate way than tumor burden, potentially allowing individualization postmastectomy comprehensive node field irradiation. Future clinical trials should incorporate both burden when examining strategies.