Delivery of paclitaxel from cobalt–chromium alloy surfaces without polymeric carriers

摘要: Polymer-based carriers are commonly used to deliver drugs from stents. However, adverse responses polymer coatings have raised serious concerns. This research is focused on delivering stents without using polymers or any carriers. Paclitaxel (PAT), an anti-restenotic drug, has strong adhesion towards a variety of material surfaces. In this study, we utilized such natural property PAT attach these molecules directly cobalt–chromium (Co–Cr) alloy, ultra-thin stent strut material. Four different groups drug coated specimens were prepared by adding Co–Cr alloy surfaces: Group-A (PAT coated, unheated, and ethanol cleaned); Group-B heat treated, Group-C not Group-D treated cleaned). vitro release was investigated high performance liquid chromatography. Groups A B showed sustained for up 56 days. simple cleaning procedure after deposition can remove the loosely bound crystals surfaces thereby allowing remaining strongly be released at rate. The treatment coating further improved stability allowed delivered much slower rate, especially during initial 7 which cleaned in ethanol, C D, burst release. thoroughly characterized scanning electron microscopy, atomic force X-ray photoelectron spectroscopy. These techniques collectively useful studying morphology, distribution, attachment Thus, study suggests potential paclitaxel