Regulation of the Expression of Type III Secretion Systems: an Example from Pseudomonas aeruginosa

摘要: This chapter presents a general overview of type III secretion system (T3SS) regulation in the main pathogenic bacteria, and focuses on different aspects T3SS gene expression Pseudomonas aeruginosa. Pathogenic bacteria occupy very infection foci; for instance, animal pathogens Shigella spp. Salmonella live intracellularly after successful invasion, whereas Yersinia spp., P. aeruginosa, enteropathogenic Escherichia coli (EPEC) predominantly remain extracellular. Therefore, stimuli could be used to up or downregulate genes: temperature, divalent cations, host cell contact, serum, other factors. Although mechanism by which metabolic pathways influence virulence is unclear, example aeruginosa detailed facilitate progress that field. It has been shown dependent density exsCEBA operon decreases rapidly second part stationary phase, also indole-3-acetic acid (IAA), naphthalenacetic, 3-hydroxykynurenine inhibit at millimolar concentrations. In 2005, Wu coworkers proposed opportunistic pathogen adapt sensing alterations immune function respond enhancing phenotype. Despite large number genes only minority have precise role. Both fundamental applied research can make inhibition as one first new antibacterial therapeutics.