Phylogeography of Avian influenza A H9N2 in China

摘要: During the past two decades, avian influenza A H9N2 viruses have spread geographically and ecologically in China. Other than its current role causing outbreaks poultry sporadic human infections by direct transmission, virus could also serve as an progenitor for novel including H5N1, H7N9 H10N8. Hence, is becoming a notable threat to public health. However, despite multiple lineages genotypes that were detected previous studies, migration dynamics of China unclear. Increasing such knowledge would help us better prevent control well other future potentially threatening from spreading across The objectives this study determine source, patterns, demography history circulated Using Bayesian phylogeography framework, we showed mainland may originated Hong Kong Special Administrative Region (SAR). Southern China, most likely Guangdong province acts primary epicentre strains whole country, eastern Jiangsu province, important secondary source seed outbreaks. Our inference suggests during long-term process, evolved into diverse then experienced selective sweep, which reduced genetic diversity. Importantly, sweep pose greater health because confer higher fitness advantages being replaced generate new through reassortment. analyses indicate migratory birds, trade transportation all contributed ongoing evolution H9N2, poses constant population, highlights need more comprehensive surveillance wild birds enhancement biosafety China’s industry.