Interleukin-13 in asthma pathogenesis.

摘要: Numerous studies have clearly shown that the Th2 cytokine, interleukin (IL)-13, is central regulator of allergic diathesis. Initial in animal models disease provided compelling evidence IL-13, independent other cytokines, was both necessary and sufficient to induce all features asthma. The importance IL-13 disorders humans supported by consistent associations between tissue levels genetic variants gene with asthma related traits. With preponderance continuing support disorders, attention now turned toward understanding mechanisms which this cytokine might mediate pathophysiologic disease. emerging paradigm induces response via its actions on epithelial cells smooth muscle cells, not through traditional effector pathways involving eosinophils IgE-mediated events. In light these recent developments, review our current role pathogenesis explored, a particular focus new insights into