Platelet activation marker

摘要: Atherosclerosis is the leading cause of death in patients with diabetes mellitus, increasing mortality all forms disease. Classical risk factors, including hyperlipidemia, hypertension and obesity, do not completely account for increased incidence atherosclerosis diabetes. Some platelet activation markers such as CD62P, CD63, PAC-1, Annexin V platelet-derived microparticles (PDMP) are elevated diabetes, since diabetic platelets often have sensitivity to secondary aggregation response agonist. PDMPs thought play a role clinical disease because they express phospholipids that function procoagulants. High shear stress can initiate both shedding procoagulant-containing PDMP, suggesting PDMP generation by high occurs small diseased arteries arterioles under various conditions. Platelet were significantly higher hypertensive or hyperlipidemic than controls. Selectins cell adhesion molecules also patients, these Activated may contribute development seem be useful assessment vascular damage patients.