Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease

作者: Dirk Classen-Houben , Stephen Cusack , Andrea Wolkerstorfer , Thierry Langer , Sung-Sau So

DOI:

关键词: Viral diseaseTautomerHydroxamic acidChemistryEnantiomerProdrugOrganic chemistrySalt (chemistry)

摘要: The present invention relates to a compound having the general formula I, optionally in form of pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or dsasiereomer mixture thereof, which is useful treating, ameloriating preventing viral disease. Furthermore, specific combination therapies are disclosed.

参考文章(14)
Heinz Kölbl, Hans Georg W. Leuenberger, Bertrand Nagel, A multilingual glossary of biotechnological terms : IUPAC recommendations Verlag Helvetica Chimica Acta , VCH [distributor]. ,(1995)
Cheng-Chao Pai, Albert Sun-Chi Chan, Jian-Ying Qi, Li-Sheng Deng, Wen-Zao Li, Bin Sun, Jia-Yuan Hu, Xian-Jun Li, Catalytic preparation of aryl methyl ketones using a molecular oxygen-containing gas as the oxidant ,(2002)
Kerry Ellen Benenato, Valerie Marone, Michael Robin Hale, Pamela Hill, Matthew Miller, Allison Laura Choy, Hydroxamic acid derivatives as gram-negative antibacterial agents ,(2010)
Makoto Kawai, Toshio Fujishita, Minako Mikamiyama, Toshiyuki Akiyama, Substituted 3-hydroxy-4-pyridone derivative ,(2010)
Joanne E. Tomassini, Gerald S. Ponticello, Harold G. Selnick, John J. Baldwin, Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease ,(1994)
Yukihito Sumino, Moriyasu Masui, Kazuya Okamoto, Toshiyuki Akiyama, Process for producing pyrone and pyridone derivatives ,(2010)
Aymn E. Rashad, Ahmed H. Shamroukh, Randa E. Abdel-Megeid, Ahmed Mostafa, Rabeh El-Shesheny, Ahmed Kandeil, Mohamed A. Ali, Klaus Banert, Synthesis and screening of some novel fused thiophene and thienopyrimidine derivatives for anti-avian influenza virus (H5N1) activity. European Journal of Medicinal Chemistry. ,vol. 45, pp. 5251- 5257 ,(2010) , 10.1016/J.EJMECH.2010.08.044
Ann J. Stemmler, Jeff W. Kampf, Martin L. Kirk, Bassel H. Atasi, Vincent L. Pecoraro, The Preparation, Characterization, and Magnetism of Copper 15-Metallacrown-5 Lanthanide Complexes. Inorganic Chemistry. ,vol. 38, pp. 2807- 2817 ,(1999) , 10.1021/IC9800233
Ewa Lipczynska-Kochany, Hiizu Iwamura, Kazuhiko Takahashi, Atsushi Hakura, Yutaka Kawazoe, Mutagenicity of pyridine- and quinoline-carbohydroxamic acid derivatives Mutation Research\/genetic Toxicology. ,vol. 135, pp. 139- 148 ,(1984) , 10.1016/0165-1218(84)90114-9
Shahid Abbas Abbasi, Heterocyclic hydroxamic acids: Effect of temperature on the protonation equilibria Thermochimica Acta. ,vol. 29, pp. 184- 187 ,(1979) , 10.1016/0040-6031(79)85031-5