Estimation of thyroxine output by the thyroid glands of normal and adrenalectomized rats by means of a simple cooling test.

摘要: Adrenalectomy, administration of propylthiouracil (PTU), or a combination these two treatments significantly increased rate cooling rats restrained and subjected to air at 5 °C. Propylthiouracil 55% above that untreated control while adrenalectomy 84%. The 94%. Dead cooled 201% faster than rats. Administration graded doses thyroxine both adrenalectomized PTU-treated normal indicated 1.9 4.4 μg/day respectively was required return comparable controls. These are therefore best estimates daily outputs by thyroid glands animals. results suggest is accompanied diminished function.