Molecular Biology of Epstein-Barr Virus

摘要: This chapter discusses the pathologies associated with Epstein-Barr virus (EBV) infection. Infection EBV usually occurs early in childhood and results an asymptomatic The majority of isolates Western communities are type 1, while 2 appear to be largely restricted equatorial Africa Papua New Guinea. EBV, contrast herpes simplex (HSV), has a limited host range. restriction is at least partially due absence cellular receptor CD21 for which also C3d component complement. In addition essential components, DNA encodes two genes that augment viral replication. It likely role BHRF1 protect latently infected cells vivo when they switch from latent infection lytic there or very low Bcl2 expression, thus delaying apoptosis induced by replication ensuring productive EBV-transformed lymphoblastoid cell lines (LCLs) express nine proteins small RNAs grown tissue culture. expressed either nucleus (Epstein-Barr nuclear antigen [EBNA]) plasma membrane (latent protein [LMP]), recent work elucidated many their functions. EBNA1 binds 20-bp sequence as homodimer. structure bound been solved. Key elements determination discussed chapter.