NF-kappaB and STAT3 signaling in glioma: targets for future therapies.
作者： George P Atkinson , Susan E Nozell , Etty (Tika) N Benveniste
DOI: 10.1586/ERN.10.21
关键词: stat 、 JAK-STAT signaling pathway 、 Glioblastoma 、 Signal transduction 、 Neuroscience 、 Nf kappab 、 NF-κB 、 Cytokine 、 Biology 、 Glioma
摘要: Glioblastoma remains the most clinically challenging tumor of CNS, as evidenced by dismal change in overall survival over past 50 years. However, recent advances high-throughput screening techniques have given rise to a wealth new information regarding aberrant signaling pathways that drive phenotype. Two these so-called 'oncopathways' are NF-kappaB and JAK/STAT. This review will describe basic mechanisms pathways, explore relevance JAK/STAT glioblastoma, look ahead experimental compounds integrate our knowledge into existing therapies.
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