Kaposi Sarcoma of Childhood: Inborn or Acquired Immunodeficiency to Oncogenic HHV‐8
作者： Carolyn C Jackson , Mark A Dickson , Mahan Sadjadi , Antoine Gessain , Laurent Abel
DOI: 10.1002/PBC.25779
关键词: Sarcoma 、 T cell deficiency 、 Pathogenesis 、 Immunology 、 Membrane protein 、 Wiskott–Aldrich syndrome protein 、 Acquired immunodeficiency syndrome (AIDS) 、 Medicine 、 Immunity 、 Malignancy 、 Virology
摘要: Kaposi sarcoma (KS) is an endothelial malignancy caused by human herpes virus-8 (HHV-8) infection. The epidemic and iatrogenic forms of childhood KS result from a profound acquired T cell deficiency. Recent studies have shown that classic can rare single-gene inborn errors immunity, with mutations in WAS, IFNGR1, STIM1, TNFRSF4. pathogenesis the endemic form has remained elusive. We review its relationship to inherited immunodeficiency oncogenic HHV-8.
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