D-methadone and its derivatives for use in the treatment of disorders of the nervous system
作者： Inturrisi Charles E , Manfredi Paolo L
DOI:
关键词: Enantiomer 、 Methadone 、 Normethadone 、 Pharmacology 、 Nervous system 、 Noracetylmethadol 、 Acetylmethadol 、 Medicine
摘要: The present invention relates to a method of treating or preventing cellular dysfunction and death caused by genetic, degenerative, toxic, traumatic, ischemic, infectious, neoplastic inflammatory diseases aging - their neurological symptoms manifestations, which includes administering d-methadone, beta-d-methadol, alpha-l-methadol, beta-l-methadol, alpha-d-methadol, acetylmethadol, d-alpha-acetylmethadol, l-alpha-acetylmethadol, beta-d-acetylmethadol, beta-l-acetylmethadol, d-alpha-normethadol, l-alpha normethadol, noracetylmethadol, dinoracetylmethadol, methadol, dinormethadol, EDDP, EMDP, d-isomethadone, normethadone, N-methyl-methadone, N-methyl-d-methadone, N-methyl-l-methadone, l-moramide, levopropoxyphene, pharmaceutically acceptable salts, mixtures thereof, including deuterated tritium analogues, whether isolated from its enantiomer synthesized de novo.
lens.org 参考文章(226)
DAVID A. SULLIVAN, BENJAMIN D. SULLIVAN, JAMES E. EVANS, FRANK SCHIRRA, HIROKO YAMAGAMI, MENG LIU, STEPHEN M. RICHARDS, TOMO SUZUKI, DEBRA A. SCHAUMBERG, ROSE M. SULLIVAN, M. REZA DANA, Androgen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye Annals of the New York Academy of Sciences. ,vol. 966, pp. 211- 222 ,(2002) , 10.1111/J.1749-6632.2002.TB04217.X
Gessica Sala, Federica Trombin, Simone Beretta, Lucio Tremolizzo, Paola Presutto, Monica Montopoli, Marianna Fantin, Andrea Martinuzzi, Valerio Carelli, Carlo Ferrarese, Antioxidants partially restore glutamate transport defect in leber hereditary optic neuropathy cybrids Journal of Neuroscience Research. ,vol. 86, pp. 3331- 3337 ,(2008) , 10.1002/JNR.21773
Ole A. Andreassen, Jo Waage, Bente Finsen, Hugo A. Jørgensen, Memantine attenuates the increase in striatal preproenkephalin mRNA expression and development of haloperidol-induced persistent oral dyskinesias in rats. Brain Research. ,vol. 994, pp. 188- 192 ,(2003) , 10.1016/J.BRAINRES.2003.09.035
JOSEPH BIEDERMAN, MICHAEL C. MONUTEAUX, ERIC MICK, THOMAS SPENCER, TIMOTHY E. WILENS, JULIE M. SILVA, LINDSEY E. SNYDER, STEPHEN V. FARAONE, Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up study. Psychological Medicine. ,vol. 36, pp. 167- 179 ,(2006) , 10.1017/S0033291705006410
A Laurel Gorman, Kathryn J Elliott, Charles E Inturrisi, The D- And L-Isomers of Methadone Bind to the Non-Competitive Site on the N-methyl-D-aspartate (NMDA) Receptor in Rat Forebrain and Spinal Cord Neuroscience Letters. ,vol. 223, pp. 5- 8 ,(1997) , 10.1016/S0304-3940(97)13391-2
I. Bezprozvanny, T. Klockgether, Therapeutic prospects for spinocerebellar ataxia type 2 and 3. Drugs of The Future. ,vol. 34, pp. 991- 999 ,(2009) , 10.1358/DOF.2009.034.12.1443434
Dhumal Uttareshvar Mahaling, Madole Mahesh Basavaraj, Aher Jagdish Bika, Comparison of lipid profile in different grades of non-alcoholic fatty liver disease diagnosed on ultrasound Asian pacific Journal of Tropical Biomedicine. ,vol. 3, pp. 907- 912 ,(2013) , 10.1016/S2221-1691(13)60177-X
Herbert H. Seltzman, Steven D. Wyrick, Colin G. Pitt, The preparation of tritium labeled methadone and its metabolites Journal of Labelled Compounds and Radiopharmaceuticals. ,vol. 18, pp. 1365- 1377 ,(1981) , 10.1002/JLCR.2580180913
Abdulrahman Almatroudi, Stephen M Husbands, Christopher P Bailey, Sarah J Bailey, Combined administration of buprenorphine and naltrexone produces antidepressant-like effects in mice. Journal of Psychopharmacology. ,vol. 29, pp. 812- 821 ,(2015) , 10.1177/0269881115586937
Ami V. Patel, Tao Huang, Robin F. Krimm, Lingual and palatal gustatory afferents each depend on both BDNF and NT‐4, but the dependence is greater for lingual than palatal afferents The Journal of Comparative Neurology. ,vol. 518, pp. 3290- 3301 ,(2010) , 10.1002/CNE.22400