Beyond the antibody: B cells as a target for bacterial infection

摘要: It is well established that B cells play an important role during infections beyond antibody production. produce cytokines and are APCs for T cells. Recently, it has become clear several pathogenic bacterial genera, such as Salmonella, Brucella, Mycobacterium, Listeria, Francisella, Moraxella, Helicobacter, have evolved mechanisms micropinocytosis induction, inflammasome down-regulation, inhibitory molecule expression, apoptosis anti-inflammatory cytokine secretion to manipulate cell functions influencing immune responses. In this review, we summarize our current understanding of targets infection the by which a niche survival replication away from extracellular responses complement antibodies.