Lobectomy is superior to segmentectomy for peripheral high grade non-small cell lung cancer ≤2 cm.

摘要: Background Current practice guidelines recommend the following criteria for segmentectomy non-small cell lung cancer (NSCLC): size ≤2 cm, margins ≥2 cm and no lymph node involvement. We sought to further stratify selection small peripheral high-grade tumors. Methods This retrospective database study was conducted using Surveillance, Epidemiology End Results (SEER) database. queried patients with (poorly differentiated/undifferentiated) pathological (p)T1a/b NSCLC (tumor cm), who underwent either lobectomy or between 2004 2015. Patients node-positive disease those received any form of induction adjuvant treatments were excluded. A total 4,332 met inclusion criteria, 3,977 (91.8%) treated 355 (8.2%) segmentectomy. In a propensity matched pair analysis 640 patients, (n=320) showed significantly improved 5-year survival 45.9% vs. 33.8% (n=320), P<0.01. multivariate Cox regression analysis, associated (HR: 0.84, 95% CI: 0.714-0.989, P=0.036). Interestingly, married status, adenocarcinoma histology, number nodes sampled better (P<0.05), while advanced age male gender had worse outcomes (P<0.05). Conclusions For high grades tumor differentiation, is long-term as compared Additional data needed various histologies their respective allow