Heparin-associated Autoantibodies

摘要: Publisher Summary This chapter provides an overview of heparin-associated autoantibodies. The studies include intensive efforts to standardize the assay, define associations with disease or clinical presentation, and characterize antigenic biological properties these antibodies Heparin-induced thrombocytopenia (HIT) interesting model autoimmunity in which a heterologous mucopolysaccharide combines normal endogenous protein released specific settings generate autoantibodies susceptible, but immunologically ‘normal” individuals cause thrombosis. HIT platelets aggregate secrete serotonin vitro. release assay (SRA) more objective endpoint than platelet aggregation that have variable sensitivity specificity.