Endothelin in Nondiabetic Chronic Kidney Disease: Preclinical and Clinical Studies
作者： Geoff J. Culshaw , Iain M. MacIntyre , Neeraj Dhaun , David J. Webb
DOI: 10.1016/J.SEMNEPHROL.2015.03.002
关键词: Incidence (epidemiology) 、 Endothelin receptor 、 Blood pressure 、 Inflammation 、 Internal medicine 、 Pathology 、 Oncology 、 Medicine 、 Endothelin receptor antagonist 、 Kidney disease 、 Fibrosis 、 Proteinuria
摘要: The incidence and prevalence of chronic kidney disease (CKD) is increasing. Despite current therapies, many patients with CKD have suboptimal blood pressure, ongoing proteinuria, develop progressive renal dysfunction. Further therapeutic options therefore are required. Over the past 20 years endothelin (ET) system has become a prime target. Experimental models shown that ET-1, acting primarily via endothelin-A receptor, plays an important role in development glomerular injury, fibrosis, inflammation. Subsequent animal early clinical studies using ET-receptor antagonists suggested theses therapies may slow progression through pressure proteinuria reduction. This review examines literature regarding ET nondiabetic CKD.
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