Organelle-specific injury to melanin-containing cells in human skin by pulsed laser irradiation.

摘要: Physical models predict that ultraviolet laser radiation of appropriately brief pulses can selectively alter melanin-containing cellular targets in human skin. Skin normal volunteers was exposed to (20 nanosecond) 351-nm wave length from a XeF excimer laser, predicting those cells containing the greatest quantities melanized melanosomes (lower half epidermis) would be damaged. Transmission electron microscopy revealed earliest alteration immediate disruption melanosomes, both within melanocytes and basal keratinocytes. This dose dependent culminated striking degenerative changes these cells. Superficial keratinocytes Langerhans were not affected. It concluded is capable organelle-specific injury melanosomes. These findings may have important clinical implications treatment benign malignant pigmented lesions by radiations defined lengths pulse durations.