Spared nerve injury : an animal model of persistent peripheral neuropathic pain
作者： Isabelle Decosterd , Clifford J. Woolf
DOI: 10.1016/S0304-3959(00)00276-1
关键词: Medicine 、 Neuropathic pain 、 Sciatic nerve 、 Peripheral neuropathy 、 Sural nerve 、 Sciatic nerve injury 、 Denervation 、 Epineurial repair 、 Anesthesia 、 Nerve injury
摘要: Peripheral neuropathic pain is produced by multiple etiological factors that initiate a number of diverse mechanisms operating at different sites and at different times and expressed both within, and across different disease states. Unraveling the mechanisms involved requires laboratory animal models that replicate as far as possible, the different pathophysiological changes present in patients. It is unlikely that a single animal model will include the full range of neuropathic pain mechanisms. A feature of several animal models of peripheral …
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