miR miR on the wall, who’s the most malignant medulloblastoma miR of them all?

摘要: microRNAs (miRNAs) have wide-ranging effects on large-scale gene regulation. As such, they play a vital role in dictating normal development, and their aberrant expression has been implicated cancer. There large body of research the miRNAs medulloblastoma, most common malignant brain tumor childhood. The identification 4 molecular subgroups with distinct biological, genetic, transcriptional features revolutionized field medulloblastoma over past 5 years. Despite this, growing largely focused clinical entity single disease rather than subgroups. This review begins by highlighting development progresses to explore myriad implications Medulloblastoma is characterized increased proliferation, inhibition apoptosis, maintenance stemness programs-features that are inadvertently regulated altered patterns miRNAs. aims contextualize work within framework goal this stimulate new areas research, including potential therapeutics, rapidly field.