Neurobehavioral effects of intrauterine mercury exposure: potential sources of bias.
作者： P. Grandjean , P. Weihe
关键词: Gestation period 、 Cord blood 、 Risk factor 、 Low birth weight 、 Cohort 、 Pregnancy 、 Mercury (element) 、 Physiology 、 Medicine 、 Confounding
摘要: Sources of bias were examined in a study neurobehavioral effects intrauterine exposure to methyl mercury the Faroe Islands. The cohort 1000 children was born during 21-month period and did not differ from Faroese births general as regards major obstetrical parameters. However, high concentrations cord blood associated with increased birth weight, presumably because other constituents marine fish may cause prolongation gestation period. Thus, exposures somewhat protected against low weight its risks. Less than 25% women indicated occasional alcohol drinking pregnancy, thus suggesting limited fetal this risk factor. maternal caused decrease blood, probably toxicokinetic interaction between ethanol mercury. Any alcohol-related effect on development would then be lower levels exposures. these confounders tend results toward null hypothesis.
harvard.edu
elsevier.com
sci-hub.se 参考文章(11)
M S Kramer, Determinants of low birth weight: methodological assessment and meta-analysis. Bulletin of The World Health Organization. ,vol. 65, pp. 663- 737 ,(1987)
GAIL E. MCKEOWN-EYSSEN, JOHN RUEDY, ALAN NEIMS, METHYL MERCURY EXPOSURE IN NORTHERN QUEBEC: II. NEUROLOGIC FINDINGS IN CHILDREN American Journal of Epidemiology. ,vol. 118, pp. 470- 479 ,(1983) , 10.1093/OXFORDJOURNALS.AJE.A113652
ANDERS FOLDSPANG, JENS C. HANSEN, DIETARY INTAKE OF METHYLMERCURY AS A CORRELATE OF GESTATIONAL LENGTH AND BERTH WEIGHT AMONG NEWBORNS IN GREENLAND American Journal of Epidemiology. ,vol. 132, pp. 310- 317 ,(1990) , 10.1093/OXFORDJOURNALS.AJE.A115660
T W Clarkson, J D Dunn, L Magos, Interaction of ethanol and inorganic mercury: generation of mercury vapor in vivo. Journal of Pharmacology and Experimental Therapeutics. ,vol. 216, pp. 19- 23 ,(1981)
J B Hursh, T W Clarkson, J Allen, S Demuth, M R Greenwood, The effect of ethanol on the fate of mercury vapor inhaled by man. Journal of Pharmacology and Experimental Therapeutics. ,vol. 214, pp. 520- 527 ,(1980)
P. Grandjean, P. Weihe, P. J. Jørgensen, T. Clarkson, E. Cernichiari, T. Viderø, Impact of Maternal Seafood Diet on Fetal Exposure to Mercury, Selenium, and Lead Archives of Environmental Health. ,vol. 47, pp. 185- 195 ,(1992) , 10.1080/00039896.1992.9938348
HaraldS Hansen, Benny Jensen, Steffen Sommer, LisbethB Knudsen, SjurdurF Olsen, ThorkildI.A Sørensen, NielsJ Secher, Intake of marine fat, rich in (n-3)-polyunsaturated fatty acids, may increase birthweight by prolonging gestation. The Lancet. ,vol. 328, pp. 367- 369 ,(1986) , 10.1016/S0140-6736(86)90055-3
Troels Lyngbye, Ole Noerby Hansen, Philippe Grandjean, Neurological deficits in children: Medical risk factors and lead exposure Neurotoxicology and Teratology. ,vol. 10, pp. 531- 537 ,(1988) , 10.1016/0892-0362(88)90089-X
Kåre Julshamn, Allan Andersen, Ole Ringdal, Jacup Mørkøre, Trace elements intake in the Faroe Islands. I. Element levels in edible parts of pilot whales (Globicephalus meleanus). Science of The Total Environment. ,vol. 65, pp. 53- 62 ,(1987) , 10.1016/0048-9697(87)90160-4
Ann P. Streissguth, Helen M. Barr, Paul D. Sampson, Moderate Prenatal Alcohol Exposure: Effects on Child IQ and Learning Problems at Age 7 1/2 Years Alcoholism: Clinical and Experimental Research. ,vol. 14, pp. 662- 669 ,(1990) , 10.1111/J.1530-0277.1990.TB01224.X