Effects of Protein Kinase-C-Related Adrenocorticotropin Secretagogues and Interleukin-1 on Proopiomelanocortin Gene Expression in Rat Anterior Pituitary Cells*
作者： TOSHIHIRO SUDA , FUMIKO TOZAWA , TSUYAKO USHIYAMA , NAOKI TOMORI , TAKASHI SUMITOMO
关键词: Internal medicine 、 Pituitary gland 、 Angiotensin II 、 Arginine 、 Anterior pituitary 、 Phorbol 、 Proopiomelanocortin 、 Peptide hormone 、 Vasopressin 、 Endocrinology 、 Biology 、 Molecular biology
摘要: To examine the effects of cAMP-independent protein kinase-C system and interleukin-1 (IL-1) on secretion ACTH POMC gene expression in cultured rat anterior pituitary (AP) cells, AP cells were incubated with CRF, 8-bromo-cAMP, arginine vasopressin, angiotensin II, norepinephrine, phorbol 12-myristate 13-acetate. After 15 h incubation, CRF 8-bromo-cAMP increased both release mRNA level. Arginine or 13-acetate stimulated but failed to increase basal CRFstimulated levels. Human recombinant IL-lα -β neither nor levels after 3 incubation. 100 pM 10 nM release. However, significantly elevated only by IL-1β. These results suggest that CRF-cAMP plays a major role cAMP-independ...
oup.com
sci-hub.se 参考文章(33)
WYLIE VALE, CATHERINE RIVIER, MARVIN R. BROWN, JOACHIM SPIES, GEORGE KOOB, LARRY SWANSON, LOUISE BILEZIKJIAN, FLOYD BLOOM, JEAN RIVIER, Chemical and Biological Characterization of Corticotropin Releasing Factor Recent Progress in Hormone Research. ,vol. 39, pp. 245- 270 ,(1983) , 10.1016/B978-0-12-571139-5.50010-0
G Schreiber, G Howlett, M Nagashima, A Millership, H Martin, J Urban, L Kotler, The acute phase response of plasma protein synthesis during experimental inflammation. Journal of Biological Chemistry. ,vol. 257, pp. 10271- 10277 ,(1982) , 10.1016/S0021-9258(18)34015-8
G Aguilera, J P Harwood, J X Wilson, J Morell, J H Brown, K J Catt, Mechanisms of action of corticotropin-releasing factor and other regulators of corticotropin release in rat pituitary cells. Journal of Biological Chemistry. ,vol. 258, pp. 8039- 8045 ,(1983) , 10.1016/S0021-9258(20)82024-9
A B Abou-Samra, J P Harwood, V C Manganiello, K J Catt, G Aguilera, Phorbol 12-myristate 13-acetate and vasopressin potentiate the effect of corticotropin-releasing factor on cyclic AMP production in rat anterior pituitary cells. Mechanisms of action. Journal of Biological Chemistry. ,vol. 262, pp. 1129- 1136 ,(1987) , 10.1016/S0021-9258(19)75760-3
GARY S. WAND, BETTY A. EIPPER, Effect of Chronic Secretagogue Exposure on Pro-Adrenocorticotropin/Endorphin Production and Secretion in Primary Cultures of Rat Anterior Pituitary* Endocrinology. ,vol. 120, pp. 953- 961 ,(1987) , 10.1210/ENDO-120-3-953
Philippe Kehrer, Dora Turnill, Jean-M. Dayer, Alex F. Mullen, Rolf C. Gaillard, Human Recombinant Interleukin-1Beta and -Alpha, but Not Recombinant Tumor Necrosis Factor Alpha Stimulate ACTH Release from Rat Anterior Pituitary Cells in vitro in a Prostaglandin E2 and cAMP Independent Manner Neuroendocrinology. ,vol. 48, pp. 160- 166 ,(1988) , 10.1159/000125004
ABDUL-BADI ABOU-SAMRA, KEVIN J. CATT, GRETI AGUILERA, Involvement of protein kinase C in the regulation of adrenocorticotropin release from rat anterior pituitary cells. Endocrinology. ,vol. 118, pp. 212- 217 ,(1986) , 10.1210/ENDO-118-1-212
T Suda, F Tozawa, M Yamada, T Ushiyama, N Tomori, T Sumitomo, Y Nakagami, H Demura, K Shizume, Effects of corticotropin-releasing hormone and dexamethasone on proopiomelanocortin messenger RNA level in human corticotroph adenoma cells in vitro. Journal of Clinical Investigation. ,vol. 82, pp. 110- 114 ,(1988) , 10.1172/JCI113557
Toshihiro Suda, Fumiko Tozawa, Masao Yamada, Tsuyako Ushiyama, Naoki Tomori, Takashi Sumitomo, Yuriko Nakagami, Kazuo Shizume, In vitro study on proopiomelanocortin messenger RNA levels in cultured rat anterior pituitary cells. Life Sciences. ,vol. 42, pp. 1147- 1152 ,(1988) , 10.1016/0024-3205(88)90609-1
R Sapolsky, C Rivier, G Yamamoto, P Plotsky, W Vale, Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science. ,vol. 238, pp. 522- 524 ,(1987) , 10.1126/SCIENCE.2821621