Gα12- and Gα13-Subunits of Heterotrimeric G-Proteins A Novel Family of Oncogenes

摘要: Certain polypeptide growth factor receptors possess an intrinsic protein tyrosine kinase activity (1), and a large body of information implicates these in normal aberrant cell growth. As such, number oncogenes have been found to code for altered forms (2–4), their ligands (5), or molecules thought participate growth-promoting pathways (6). Another family structurally related cell-surface is linked heterotrimeric G-proteins, this class has traditionally tissue-specific, fully differentiated functions, such as photoreception, chemoreception, neurotransmission (7). However, G-protein-coupled (GPCRs) are also expressed most proliferating cells, they implicated embryogenesis stimulation (8). Furthermore, the vast majority GPCRs identified so far exhibit common structural motif consisting presence seven transmembrane-spanning domains (7), property that was predicted product mas oncogene on basis its nucleotide sequence (9). This finding provided first link between cellular transformation GPCRs.