Frequency-Dependent Effects of Class III Antiarrhythmic Agents as Assessed by MAP Recordings — Possible Advantages of lKs Blockade
作者： Claus Schmitt , Jürgen Schreieck , Martin Karch , Bernhard Zrenner
DOI: 10.1007/978-3-642-60851-3_6
关键词: Amiodarone 、 Potassium current 、 Blockade 、 Sematilide 、 Antiarrhythmic agent 、 Medicine 、 Dofetilide 、 Class iii antiarrhythmic 、 Delayed rectifier 、 Pharmacology
摘要: With the exception of amiodarone, most class III agents are blockers, blocking rapid (r) component delayed rectifier potassium current (IK). Selective IKr blockers include, for example, d-sotalol and newer substances like dofetilide, sematilide, E-4031 or MK-499 [1].
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