Crystallographic structure of the octameric histone core of the nucleosome at a resolution of 3.3 Å
作者： R. Burlingame , W. Love , B. Wang , R Hamlin , H. Nguyen
关键词: Histone H2B 、 Histone H3 、 Histone octamer 、 Tetramer 、 Nucleosome 、 Histone 、 Histone H2A 、 Crystallography 、 Histone H4 、 Biology
摘要: The structure of the (H2A-H2B-H3-H4)2 histone octamer has been determined by means x-ray crystallographic techniques at a resolution 3.3 angstroms. is prolate ellipsoid 110 angstroms long and 65 to 70 in diameter, its general shape that rugby ball. size are radically different from those earlier studies. most striking feature tripartite organization, is, central (H3-H4)2 tetramer flanked two H2A-H2B dimers. DNA helix, placed around path suggested features on surface protein, appears like spring holding dimers either end tetramer.
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