Ventricular performance and biochemical alteration of regional ischemic myocardium after reperfusion in the pig

摘要: Reperfusion of acutely ischemic myocardium may cause profound alterations in left ventricular wall performance and metabolism. This study evaluates regional thickness, analyzes metabolic biochemical alterations, examines tissue hemorrhage during 15, 30, 120 minutes myocardial ischemia, each followed by reperfusion. after 15 ischemia showed nearly normal thickening motion, intact function, no hemorrhage. However, reperfusion 30 was associated with failure to resume systolic diastolic motion. Furthermore, adverse zone hemorrhaging increased proportionally the duration ischemia. These findings suggest critical damage occurring between an animal model without preexisting coronary collateral circulation. The observed changes are consistent irreversible cell membrane defects, allowing calcium ion accumulation thus adversely affecting relaxation thickening.