Molecular mechanisms of chromosomal rearrangement during primate evolution

摘要: Breakpoint analysis of the large chromosomal rearrangements which have occurred during primate evolution promises to yield new insights into underlying mechanisms mutagenesis. Comparison these evolutionary breakpoints with those that are disease-associated in humans, and occur either meiotic or mitotic cell division, should help identify basic mechanistic similarities as well differences. It has recently become clear segmental duplications (SDs) had a very significant impact on genome plasticity evolution. In comparisons human chimpanzee genomes, SDs been found flanking regions 70–80% inversions ∼40% deletions/duplications. A strong spatial association between primate-specific also evident from other mammalian genomes. The lineage-specific hyperexpansion certain observed genomes human, chimpanzee, gorilla gibbon is indicative intrinsic instability some primates. However, since many map lacking SDs, but containing interspersed high-copy repetitive sequence elements such SINEs, LINEs, LTRs, α-satellites (AT) n repeats, we may infer range different molecular probably involved promoting breakage