Clinically and pharmacologically relevant interactions of antidiabetic drugs

摘要: Patients with type 2 diabetes mellitus often require multifactorial pharmacological treatment due to different comorbidities. An increasing number of concomitantly taken medications elevate the risk patient experiencing adverse drug effects or interactions. Drug interactions can be divided into pharmacokinetic and pharmacodynamic affecting cytochrome (CYP) enzymes, absorption properties, transporter activities receptor affinities. Furthermore, nutrition, herbal supplements, patient's age gender are clinical importance. Relevant predominantly related sulfonylureas, thiazolidinediones glinides. Although metformin has a very low interaction potential, caution is advised when drugs that impair renal function used concomitantly. With exception saxagliptin, dipeptidyl peptidase-4 (DPP-4) inhibitors also show but all P-glycoprotein should caution. Incretin mimetics sodium-glucose cotransporter-2 (SGLT-2) comprise potential therefore recommended as an ideal combination partner from clinical-pharmacologic point view.