Dissociation of IGF2 and H19 imprinting in human brain
作者： Nga V Pham , Mai T Nguyen , Ji-Fan Hu , Thanh H Vu , Andrew R Hoffman
DOI: 10.1016/S0006-8993(98)00783-5
关键词: Endocrinology 、 Genomic imprinting 、 Human brain 、 Central nervous system 、 Choroid plexus 、 Internal medicine 、 Pons 、 Raphe nuclei 、 Imprinting (psychology) 、 Biology 、 Insulin-like growth factor 2
摘要: The human IGF2 and H19 genes are imprinted in most normal tissues. Alterations of genomic imprinting or loss (LOI) have been observed a number malignant tumors. Although LOI has linked to tumorigenesis, also choroid plexus leptomeninges mouse brain. We therefore analyzed the allelic expression both fetal brain different regions adult In brains fetuses 6-12 weeks gestation, were transcribed from parental alleles. contrast, strictly monoallelic was all other tissues, suggesting tissue-specific central nervous system. brain, region-specific. expressed alleles pons, but not globus palludus, Raphe nucleus hypothalamus. drastically reduced compared detectable only pons palludus. contrast IGF2, monoallelic. Examination promoter usage indicated predominant utilization P3 reflects biallelic promoter. transcripts derived less abundant P1, however, showed pons. Our results suggest that undergo ontogenetic changes there is dissociation
elsevier.com
sci-hub.se 参考文章(41)
B Cheng, MP Mattson, IGF-I and IGF-II protect cultured hippocampal and septal neurons against calcium-mediated hypoglycemic damage. The Journal of Neuroscience. ,vol. 12, pp. 1558- 1566 ,(1992) , 10.1523/JNEUROSCI.12-04-01558.1992
Ehsan Masood, Swedish council is dismissed amid claims of malpractice. Nature. ,vol. 375, pp. 7- 7 ,(1995) , 10.1038/375007B0
P.V. Pedone, M.P. Cosma, P. Ungaro, V. Colantuoni, C.B. Bruni, R. Zarrilli, A. Riccio, Parental imprinting of rat insulin-like growth factor II gene promoters is coordinately regulated. Journal of Biological Chemistry. ,vol. 269, pp. 23970- 23975 ,(1994) , 10.1016/S0021-9258(19)51033-X
M. Brandeis, T. Kafri, M. Ariel, J.R. Chaillet, J. McCarrey, A. Razin, H. Cedar, The ontogeny of allele-specific methylation associated with imprinted genes in the mouse The EMBO Journal. ,vol. 12, pp. 3669- 3677 ,(1993) , 10.1002/J.1460-2075.1993.TB06041.X
B. Tycko, Younghui Zhang, T. Shields, Yue Hao, T. Moulton, T. Crenshaw, Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching. American Journal of Human Genetics. ,vol. 53, pp. 113- 124 ,(1993)
R Ohlsson, Colum Walsh, L Holmgren, Tj Ekstrom, F Hedborg, Overlapping patterns of IGF2 and H19 expression during human development: biallelic IGF2 expression correlates with a lack of H19 expression Development. ,vol. 120, pp. 361- 368 ,(1994) , 10.1242/DEV.120.2.361
K D Tremblay, K L Duran, M S Bartolomei, A 5’ 2 kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development Molecular and Cellular Biology. ,vol. 17, pp. 4322- 4329 ,(1997) , 10.1128/MCB.17.8.4322
R. Ohlsson, T. J. Ekstrom, Hengmi Cui, Xuri Li, PROMOTER-SPECIFIC IGF2 IMPRINTING STATUS AND ITS PLASTICITY DURING HUMAN LIVER DEVELOPMENT Development. ,vol. 121, pp. 309- 316 ,(1995)
Marja J. C. Steenman, Shirley Rainier, Craig J. Dobry, Paul Grundy, Isabelle L. Horon, Andrew P. Feinberg, Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour Nature Genetics. ,vol. 7, pp. 433- 439 ,(1994) , 10.1038/NG0794-433
Ji-Fan Hu, Thanh H. Vu, Andrew R. Hoffman, Promoter-specific Modulation of Insulin-like Growth Factor II Genomic Imprinting by Inhibitors of DNA Methylation Journal of Biological Chemistry. ,vol. 271, pp. 18253- 18262 ,(1996) , 10.1074/JBC.271.30.18253