Oxygen sensing in the brain--invited article.
作者： Frank L. Powell , B. Cindy Kim , S. Randall Johnson , Zhenxing Fu
DOI: 10.1007/978-90-481-2259-2_42
关键词: Tyrosine hydroxylase 、 Rostral ventrolateral medulla 、 Central chemoreceptors 、 Anesthesia 、 Hypoxia (medical) 、 Hypoxic ventilatory response 、 Carotid body 、 Neuroscience 、 Heme oxygenase 、 Biology 、 Pre-Bötzinger complex
摘要: Carotid body arterial chemoreceptors are essential for a normal hypoxic ventilatory response (HVR) and acclimatization to hypoxia (VAH). However, recent results show that O2-sensing in the brain is involved these responses also. rostral ventrolateral medulla, posterior hypothalamus, pre-Botzinger complex nucleus tractus solitarius contribute acute HVR. Chronic causes plasticity contributes VAH represents another time domain of central O2-sensing. The cellular molecular mechanisms remain be determined but they appear involve O2-sensitive ion channels heme oxygenase-2, which acts by different mechanism than has been described carotid body. It not known if such O2-sensitivity VAH. changes gene expression do demonstrate important control. This involves under control inducible factor-1± (HIF-1± potentially several HIF-1± targets, as erythropoietin, endothelin-1, oxygenase tyrosine hydroxylase.
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