Agent-based modeling of porous scaffold degradation and vascularization: Optimal scaffold design based on architecture and degradation dynamics

摘要: Abstract A multi-layer agent-based model (ABM) of biomaterial scaffold vascularization is extended to consider the effects degradation kinetics on blood vessel formation. describing bulk disintegration porous hydrogels incorporated into ABM. The combined degradation-angiogenesis used investigate growing networks in presence a degradable structure. Simulation results indicate that higher porosity, larger mean pore size, and rapid allow faster when not considering structural support scaffold. However, premature loss failure for material. strategy using with different rates each layer was investigated as way address this issue. Vascularization improved multi-layered compared single-layer model. ABM developed provides insight characteristics influence selection optimal geometric parameters behavior scaffolds, enables easy refinement new knowledge about underlying biological phenomena becomes available. Statement significance This paper proposes integrated structural-kinetic assessment particular angiognesis. by material disruption angiogenesis. away tissue engineering scaffolds.