L-penicillamine and rat liver transaminase activity.
作者： Vincent du Vigneaud , Edward J. Kuchinskas , Antonio Horvath
DOI: 10.1016/0003-9861(57)90480-0
关键词: Biochemistry 、 In vivo 、 In vitro 、 Penicillamine 、 Inhibitory effect 、 Enzyme assay 、 Transaminase 、 Rat liver 、 Chemistry 、 Pyridoxal
摘要: Abstract Addition of l -penicillamine to liver transaminase systems in vitro causes an inhibition enzyme activity. The inhibitory effect can be reversed by the addition increasing amounts pyridoxal 5-phosphate. Data are presented indicate a chemical combination between and 5-phosphate at pH 7.4. vivo is dependent upon presence both free sulfhydryl amino group penicillamine molecule.
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