Developmental neurotoxicity of organophosphorous pesticides: fetal and neonatal exposure to chlorpyrifos alters sex-specific behaviors at adulthood in mice.

摘要: Developmental exposure to the organophosphorous insecticide chlorpyrifos (CPF) induces long-term effects on brain and behavior in laboratory rodents. We evaluated adult mice behavioral of either fetal and/or neonatal CPF at doses not inhibiting cholinesterase. (3 or 6 mg/kg) was given by oral treatment pregnant females gestational days 15-18 offspring were treated sc (1 3 postnatal (PNDs) 11-14. Serum acetylcholinesterase (AChE) activity birth 24 h from termination treatments. On PND 70, male assessed for spontaneous motor an open-field test a socioagonistic encounter with unfamiliar conspecific. Virgin underwent maternal induction following presentation foster pups. Both sexes subjected plus-maze evaluate exploration anxiety levels. Gestational (higher doses) affected open field enhanced synergically agonistic behavior. Postnatal increased responsiveness toward pups females. Mice both exposed showed reduced response plus-maze, effect greater Altogether, developmental that do cause AChE inhibition alterations sex-specific patterns mouse species. Late PNDs 11-14 most effective causing changes. These findings support hypothesis may represent risk factor vulnerability neurodevelopmental disorders humans.