The treatment of advanced metastatic seminoma: experience in 55 cases.
作者： S D Fosså , L Borge , N Aass , N B Johannessen , A E Stenwig
DOI: 10.1200/JCO.1987.5.7.1071
关键词: Combination chemotherapy 、 Seminoma 、 Radiation therapy 、 Bone Marrow Aplasia 、 Polyneuropathy 、 Surgery 、 Stage (cooking) 、 Cisplatin 、 Medicine 、 Chemotherapy
摘要: Thirty-six of 39 previously untreated evaluable patients with advanced metastatic seminoma (stage greater than or equal to IIb) obtained a complete response (CR) and three partial (PR) after cisplatin-based combination chemotherapy without surgery/radiotherapy (group 1). After median observation time 36 months, 33 are alive no evidence disease (NED). Fifteen additional received due relapsing initial radiotherapy 2). Thirteen CR, two PR. Patients from group 1 lived significantly longer the start those 2. The rate severity treatment-related complications were comparable in both groups. most frequent nonfatal side effects Raynaud-like phenomena, polyneuropathy, myelosuppression. Four developed fatal (septicemia, bone marrow aplasia). In 12 patie...
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